Vibefarma SPMs Pro bottle with a golden softgel beside it

18-HEPE, 17-HDHA, 14-HDHA | Lipinova®

Hands holding a Vibefarma SPMs Pro bottle — beyond EPA and DHA, a new generation of omega-3

SPMs Pro composition per 2 capsules: fish oil, EPA, DHA and measured 18-HEPE, 17-HDHA and 14-HDHA from Lipinova

SPMs Pro

Name: SPMs Pro — Measured SPM Supplement | Vibefarma
Price: 64.00 USD
Availability: InStock

Measured SPM precursors — 18-HEPE, 17-HDHA and 14-HDHA — on an 825 mg omega-3 base in natural triglyceride form. Made with Lipinova®, so the fraction is quantified molecule by molecule instead of estimated. Three softgels a day; one bottle is a 30-day month.

Pre-order
This item is available for pre-order. You can order it now and shipping starts on September 15, 2026. If anything changes, we will email you before that date.

Size

Clear

BUY 3 FOR $172.80

What SPMs Pro supports

Made with Lipinova® — a marine oil standardized to measured SPM precursors — on a foundation of EPA and DHA.

Healthy inflammatory response
Supports the body’s own resolution and a healthy inflammatory response.*

Tissue health & recovery
Supports tissue health and everyday recovery.*

Immune balance
Supports a healthy immune response.*

Heart
EPA and DHA support normal heart function.*

Brain
DHA supports the maintenance of normal brain function.*

* These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

The science, in plain terms

Resolution is an active process — and it has its own molecules

Three simple steps. EPA and DHA are the substrate. The SPM precursors in SPMs Pro — 18-HEPE, 17-HDHA and 14-HDHA — are the signals your body uses to make its own resolvins, protectins and maresins. The result: a return to balance.

01 / The substrate

EPA + DHA

The raw material your body starts from.

Omega 3 Pro

→

02 / The signals

18-HEPE · 17-HDHA · 14-HDHA

The signal molecules your body converts into its pro-resolving mediators.

SPMs Pro

→

03 / Your body makes

Resolvins, protectins & maresins

The pro-resolving mediators built from those signals.

Made in your body

→

04 / The outcome

A return to balance

The body’s natural resolution phase — clean-up and repair.*

Back to balance

Adapted from Serhan et al., Nature 2014 · DOI 10.1038/nature13479

This section describes a normal physiological process for educational purposes. * These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Why it matters

The numbers behind the pathway

2000

SPMs discovered

the year Dr. Charles Serhan (Harvard) first described specialized pro-resolving mediators.

Serhan et al. Nature, 2014.

SPM families

resolvins, protectins and maresins — all built by the body from EPA and DHA.

Serhan. Nature, 2014.

~678 µg

SPMs measured per serving

ISO 17025 lab analysis of our lot — 2.7× the 255 µg minimum we guarantee on the label, and 2× the typical shelf.

Lot 1425.11 · 18-HEPE 328 · 17-HDHA 220 · 14-HDHA 130 µg.

10–12%

our target Omega-3 Index

at 8% the index is already considered desirable — that’s the floor. Our target is 10–12%, the level that keeps your body well-supplied to run its own resolution. Most people sit far below it, closer to 4%.

The 8% threshold: Schuchardt et al. Omega-3 world map: 2024 update. Prog Lipid Res. 2024;95:101286. The 10–12% target is Vibefarma’s own.

Data, not slogans

What most SPM oils won’t tell you

Most SPM supplements print a single “total SPM” figure and little else. Here’s what we show instead, per daily serving.

Parameter	Typical SPM supplement	Vibefarma SPMs Pro
SPM detail	One “total SPM” number	Every molecule, in µg: 18-HEPE · 17-HDHA · 14-HDHA
SPMs per serving	~300 µg (label)	~678 µg measured · 255 µg min. guaranteed
Molecular form	Often unstated	Natural triglyceride (TG)
Omega-3 base	Variable	825 mg (EPA 150 · DHA 300)
Batch testing	Rarely published	Lab-tested every lot (ISO 17025)

Compared with typical SPM supplements on the US market (benchmarked July 2026; underlying data documented on file for FTC substantiation).

How it’s made

Three reasons it’s a better SPM oil

Lipinova® — measured, not estimated

The SPM fraction (18-HEPE, 17-HDHA, 14-HDHA) is characterized and quantified in the finished oil — so what’s on the label is what’s in the softgel.

Natural triglyceride (TG) form

SPMs Pro delivers its omega-3 and SPM fraction in the natural triglyceride form — the form the body absorbs most efficiently. Tested each batch for potency and freshness.

Purified & safety-reviewed

Made from purified marine oil. Lipinova® is recognized as GRAS (Generally Recognized As Safe). Every batch tested for heavy metals and contaminants below safety limits.

Quick answers

The three things people ask first

What are SPMs?

Specialized Pro-resolving Mediators — signaling molecules your body makes from omega-3s (EPA/DHA) as part of its natural resolution phase. SPMs Pro delivers measured SPM precursors.

How is this different from a regular omega-3?

A standard omega-3 gives you the substrate (EPA/DHA). SPMs Pro adds a standardized, measured SPM-precursor fraction (Lipinova®) on top of that base.

How many do I take?

Three softgels a day, with meals. That’s your 90-softgel bottle for a full 30-day month.

Backed by professionals

Health professionals who support our quality

Dr. Jorge Oseguera

Functional Medicine · Mexico

Dr. Jackson Pérez

Functional Medicine · Dominican Republic

Dra. Diana Jauslin

Clinical Psychoneuroimmunology · Spain

Dr. Gerardo Rodríguez

Functional Medicine · Spain

Susana Rodrígues, RN

Functional Nursing · Portugal

Jonathan Marín

Advanced Clinical Nutrition · Spain

The health professionals shown have a professional relationship with Vibefarma and endorse the quality of our products. Their views are their own.

Composition

What’s inside and how to take it

Supplement Facts

Serving Size3 Softgels

Servings Per Container30

Amount Per Serving% DV

Calories15

Calories from Fat15

Total Fat1.5 g2%*

Fish Oil (Lipinova®)1,500 mg†

Total Omega-3 (as TG)825 mg†

EPA150 mg†

DHA300 mg†

SPMs, of which:†

18-HEPE75 µg†

17-HDHA120 µg†

14-HDHA60 µg†

* Percent Daily Values are based on a 2,000 calorie diet.
† Daily Value not established.

Directions & ingredients

Directions: Adults, take 3 softgels daily, with meals.

Other ingredients: Fish oil (Lipinova®). Softgel: DELASOL® (gelatin, humectants [sorbitol, vegetable glycerin], purified water).

Contains: Fish. Gluten-free. Lactose-free.

Every lot is analyzed. Each batch has its own pro-resolving mediator content — this lot delivers ~678 µg per serving; the label states a guaranteed 255 µg minimum.

View lab results →

⚠️ Warnings

KEEP OUT OF REACH OF CHILDREN.
DO NOT EXCEED THE RECOMMENDED DOSE.
If you are taking anticoagulant or antiplatelet medication, have a bleeding disorder, or are pregnant or nursing, consult your healthcare provider before use.
Do not use if the outer seal is broken or damaged.
Store in a cool, dry place away from direct light.

Good to know

Frequently asked questions

What are Specialized Pro-resolving Mediators (SPMs)?

SPMs are signaling molecules the body makes from omega-3 fatty acids (EPA and DHA) as part of its natural resolution phase. SPMs Pro delivers measured SPM precursors — 18-HEPE, 17-HDHA and 14-HDHA — via Lipinova®.

How is SPMs Pro different from a standard omega-3?

A standard omega-3 provides the substrate (EPA/DHA). SPMs Pro adds a standardized, quantified SPM-precursor fraction on top of an 825 mg omega-3 base per serving.

What is Lipinova®?

Lipinova® is a marine oil standardized to measured levels of SPM precursors in natural triglyceride form. It is recognized as GRAS (Generally Recognized As Safe).

How do I take it?

Adults, take 3 softgels daily, with meals. A 90-softgel bottle is a 30-day supply.

Are the SPM levels actually measured?

Yes. Unlike many “SPM” oils that only list precursors, the Lipinova® fraction is characterized and quantified: 18-HEPE 75 µg, 17-HDHA 120 µg, 14-HDHA 60 µg per 3-softgel serving.

What form is the oil in?

Natural triglyceride (TG) form — the form the body absorbs most efficiently.

Can I take it with medication, or while pregnant?

If you take anticoagulant/antiplatelet medication, have a bleeding disorder, or are pregnant or nursing, talk to your healthcare provider before use.

The deeper story